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KMID : 0043319980210050549
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Archives of Pharmacal Research
1998 Volume.21 No. 5 p.549 ~ p.554
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Changes of Tissue Factor Activity on Inflammatory Stimulus and Aging in Rat
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Han Yong-Nam
Rhee In-Kyung
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Abstract
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Tissue factor (TF), a principal initiator of the veertebrate coagulation cascade, is expressed in organ tissues, cells and blood. TF is konwn to be induced in endothelial cells, monocytes and macrophages by inflammatory stimuli and in many pathologic conditions. By using the modified method for in vido TF activity assay, we found that turpentine oil injection as an inflamatory stimulus also induced the TF activity in lung and brain tissues of rats. And the age-related increase in Tf activity was observed in healthy rat brain tissue.
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KEYWORD
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Brain tissue factor, Lung tissue factor, Inflammatory stimulus, Age-related increase of tissue factor
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